Reply To: My experience (so far) with Wellbutrin / Buproprion

[NeuroD]

@laurenshankman: Yeah, in specific, Teva/Impax’s generic bupropion XL was not properly tested by the FDA. A lower dose (150mgs) was tested, and they assumed that it would also work for higher dosages (300mgs). They then brushed off complaints by consumers until enough years of public outcry forced them to test it for real. As it turns out, no, it wasn’t as effective, in a very real sense — the generics didn’t actually deliver the full dose of the drug to the patient. It was a huge mess, and there’s a decent rundown of events on Forbes of all places.

Unfortunately, for example, in NY State Medicaid will not cover brands of anything if generics are available.

As for Bupoprion, while it may have had some effect — I can’t tell, as I was in a major depressive episode at the time that I began using it, so that’s kind of a numb blur in which I had to actually want to do anything before I could really look at how much trouble I was having with it — but if so, it’s not really eliminated it. It definitely appears to be worse because as the depression has lifted, I’m now trying to achieve goals, and aware enough to notice all the walls I’m hitting.

That would be why I’m theoretically supposed to be starting on Ritalin. But I’m now scared. More here.

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