**READ FIRST for information on Dexedrine

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Dexedrine® and Dexedrine Spansules®

What is the active ingredient?

Dextro-amphetamine

How does it work?

It has a dual role in increasing the amount of NA and DA within the synapse by preventing the reuptake of the chemicals from the presynaptic site (see chemical systems) and by increasing the production at the site of the vesicles. The short acting version, Dexedrine, comes in a tablet form which can be crushed and it has an immediate release into the gut. The capsules of Dexedrine Spansules are time release and come in two doses 10 and 15 mg.

How is it metabolized and excreted?

It is metabolized in the liver by cytochrome enzymes and excreted in the kidney.

How fast does it work and how long does it last?

What are the common side effects?

>60% of the patients may suffer from initial insomnia, appetite suppression, headaches, mild nausea, emotional lability as the medications are wearing off, a seriousness in attitude often seen as a perception of dysphoria, dry mouth, dry eyes, diarrhea, and gastric irritation. There are other side effects but they are not common.

Are there any specific major risk factors?

There are cardiovascular risk factors and possibility of sudden death IF there is a preexisting cardiac structural defect, a family history of a conduction problem and/or if the patient themselves had a sudden loss of consciousness that could only be explained by an erratic heart rate.

Can it be safely combined with other medications?

Yes, though it may potentiate the effects of similar agents including those that have a central effect on the brain (e.g. alcohol, cannabis, cocaine etc.)

If it doesn’t work, what should I do next?

Ask your doctor for guidance always but switching to another psychostimulant is usually successful. Some people just respond to another psychostimulant class, like methylphenidate, better.

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