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Re: ADD and miscarriages?

Re: ADD and miscarriages?2012-09-26T18:09:18+00:00

The Forums Forums Ask The Community ADD and miscarriages? Re: ADD and miscarriages?


Post count: 116

(FDA regarding Adderral)


Teratogenic Effects

Pregnancy Category C

Amphetamine, in the enantiomer ratio present in Adderall® (d- to l- ratio of 3:1), had no apparent effects on embryofetal morphological development or survival when orally administered to pregnant rats and rabbits throughout the period of organogenesis at doses of up to 6 and 16 mg/kg/day, respectively. These doses are approximately 1.5 and 8 times, respectively, the maximum recommended human dose of 30 mg/day [child] on a mg/m2 body surface area basis. Fetal malformations and death have been reported in mice following parenteral administration of d-amphetamine doses of 50 mg/kg/day (approximately 6 times that of a human dose of 30 mg/day [child] on a mg/m2 basis) or greater to pregnant animals. Administration of these doses was also associated with severe maternal toxicity.

A number of studies in rodents indicate that prenatal or early postnatal exposure to amphetamine (d- or d,l-), at doses similar to those used clinically, can result in long-term neurochemical and behavioral alterations. Reported behavioral effects include learning and memory deficits, altered locomotor activity, and changes in sexual function.

There are no adequate and well-controlled studies in pregnant women. There has been one report of severe congenital bony deformity, tracheo-esophageal fistula, and anal atresia (vater association) in a baby born to a woman who took dextroamphetamine sulfate with lovastatin during the first trimester of pregnancy. Amphetamines should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Nonteratogenic Effects

Infants born to mothers dependent on amphetamines have an increased risk of premature delivery and low birth weight. Also, these infants may experience symptoms of withdrawal as demonstrated by dysphoria, including agitation, and significant lassitude.

“There are no adequate and well-controlled studies in pregnant women” is key here. personally, i would not want to take any chances with my precious cargo. make sure you have plenty of support and structure in place to help compensate. and try not to beat yourself up over your difficulties. if you don’t already work with a psychologist, this would be a great time to start. also a coach can be really great to help keep you on track. make use of all the tools ( we should do anyway, but sometimes don’t, right?)

i sympathize with you, and am so sorry for your losses. i experienced mmc between my son and daughter. also was blamed on ama.

randine lewis has a great book chock full of suggestions for getting your body ready for a healthy, full term baby from an alternative med perspective. which you can use in conjunction with your fertility specialist recommendations – just be sure to let her know any herbs/supplements you may start if she wants to start you on fertility meds. there is research that supports the use of acupuncture as well to help optimize the body for pregnancy – one i remember had to do with increasing the uterine lining thickness before implantation.

perhaps being off the med for a period of time before TTC will avoid the shock the pp referred to. i would think over a few months you’ll adjust to the altered chemistry. try to simplify and steamline as much as possible. get hubby on board with supporting you however you need it. and remember this is temporary. you always have the option to go back to meds after baby is born

good luck! big hug!