Re: Cymbalta + Aderral?

[Anonymous]

From the Adderall XR product monograph: “Amphetamine is known to inhibit monoamine oxidase, whereas the ability of amphetamine and its metabolites to inhibit various P450 isozymes and other enzymes has not been adequately elucidated. In

vitro experiments with human microsomes indicate minor inhibition of CYP2D6 by amphetamine and minor

inhibition of CYP1A2, 2D6, and 3A4 by one or more metabolites. However, due to the probability of auto-

inhibition and the lack of information on the concentration of these metabolites relative to in vivo

concentrations, no predications regarding the potential for amphetamine or its metabolites to inhibit the

metabolism of other drugs by CYP isozymes in vivo can be made.”

Cymbalta drug interactions from it’s product monograph:

“• Potent inhibitors of CYP1A2 should be avoided. (7.1)

• Potent inhibitors of CYP2D6 may increase duloxetine concentrations. (7.2)

• Duloxetine is a moderate inhibitor of CYP2D6. (7.9)”

You can quickly see that both of the drugs interact with cytochrome enzymes 2D6 and 1A2 and while not contra-indicated, one should be advised to be cautious.

Always speak to your doctor before making any changes to medications. Dr. Jain provides advice generically and not for any one person. Advice does not constitute a therapeutic relationship or promise of care. Please consult the privacy policy for more information.

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