[JimC.]

Anyone????

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[JimC.]

Cortex in the USA had CX!&#( turned down as an ADD drug by the regulator, and they decided to back off. Clinical Developments

from their site…see latter paragraphs…

Cortex has completed several Phase I human safety and tolerability studies with CX717 involving over 100 subjects, including elderly subjects, tested at doses up to 1600mg per day. The plasma half-life of CX717 was found to be 9-10 hours, and CX717 exhibited an excellent safety and tolerability profile. This was followed by the initiation of six Phase IIa studies, three of which have been completed. The first CX717 Phase IIa human study was in 16 subjects and evaluated three doses of CX717 (100mg, 300mg, 1000mg) and matching placebo in a double-blinded design in normal subjects that had been sleep deprived for 28 hours. CX717 was found to be safe and well tolerated by all subjects in the sleep deprivation study, and improved alertness with the 300mg and 1000mg doses. Some cognitive tests in this same study also provided early indications of positive responses. In all doses of CX717, there was evidence of cerebral arousal without systemic activation, e.g., no increases in blood pressure or heart rate, which are commonly seen with caffeine, amphetamines and other stimulants.

The second completed Phase IIa study was a 48-subject trial evaluating excessive daytime sleepiness in a shift work simulation supported and conducted by the Defense Advanced Research Projects Agency (DARPA). In this study, CX717 did not demonstrate a significant effect on cognitive performance, although EEG studies confirmed an effect on the sleep architecture, consistent with the first sleep deprivation study.

The third Phase IIa study enrolled 68 moderate to severe adult ADHD patients in a randomized, double-blind, placebo-controlled, two-way crossover design study performed at seven U.S. sites. The primary outcome measure was the ADHD Rating Scale (ADHD-RS) which evaluated both the inattentiveness and hyperactivity symptoms. The overall ADHD-RS score showed a statistically significant effect (p<0.002) in the 800mg twice-daily dose group, with patients demonstrating a statistically significant effect on both the hyperactivity (p=0.013) and inattentiveness subscale (p=0.031) as compared to placebo. CX717 was well tolerated, and there were no serious adverse events or other significant safety concerns with either dose. This data provides the first study demonstrating Proof-of-Concept in humans with an AMPAKINE compound for the treatment of adult patients with ADHD. The Company had planned to pursue a larger Phase IIb study in adult patients with ADHD because of the advantages over the current treatments shown below:

In March 2006, CX717 was put on clinical hold by the FDA’s Division of Neurology Drug Products due to a finding in a preclinical toxicology study. Further studies by Cortex suggested that the histopathology changes seen at very high doses of CX717 in preclinical toxicology studies were due to a post mortem artifact that occurs during the tissue fixation process. In October 2007, the Neurology Division of the FDA allowed Cortex to resume enrollment of the Phase IIa Alzheimer’s disease study. The design of this study is to assess two different CX717 doses in mild-to-moderate Alzheimer’s disease (AD), with each patient receiving psychometric tests and PET scans at different time intervals while on active drug or placebo. However, the FDA’s Division of Psychiatry Products did not give approval for a clinical study in adult patients with ADHD.

In May 2007, Cortex completed a Patent License Agreement with the University of Alberta, BC for the worldwide use of AMPAKINE compounds to reverse or prevent respiratory depression induced by therapeutic doses of opiate analgesic and sedative anesthetic agents, including barbiturates without the loss of the desired therapeutic; analgesia and sedation from these respective classes of drugs commonly utilized in the majority of surgical cases performed in both hospital settings and during out –patient surgical procedures. Based on data from the use of CX717 and other AMPAKINE compounds in several animal species, AMPAKINE compounds may be broad spectrum reversal agents for multiple classes of drugs that depress central nervous system activity and lead to respiratory depression events that can be life threatening. Milder forms of breathing cessation, such as central and obstructive sleep apneas could potentially constitute additional treatment targets for the Company to pursue.

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[JimC.]

Hi Kris, been there done that. I’m 63 & male, went back to school to get technically certified for green home energy audits. test were he// for me.

1) let your instructors know of your ADD, and ask for hints on how and what to study for, even ask to take an open book exam if possible. Note: they too can be hard. Find past students and ask what they recall from tests and what tripped them up.

2) I take adderall (3 years now) and it helps me focus and stay on track mostly; re: insurance company disbelief: find a doctor that will give you a quick and dirty ADD test and have it kept on file, or if you have one now, give it to the insurance company.

3) hearing: Oh how I wish I had an answer, but I don’t. Earplugs might be best and while not perfect, they might help. When I visualize shooting all the offending noise-makers, it makes things worse, not better, so try to keep your head down and focus as best you can.

Good luck, you can do it, and when you’re done, understand you will feel like you know nothing but that’s normal. Over time you’ll learn you DO know lots and will be able to achieve new happiness and comfort. I laud you move to be around animals, good choice. My move to analytical energy audits was wrong, but that’s my issue, not yours.

What was the question again?

Good luck! Jim

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[JimC.]

I thought I might approach them and see about me being a distance-learning test dummy of sorts, willing to write a testimonial if it works at all. I’ll keep everyone posted. thanks for the tips on association with movements etc. Jim

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[JimC.]

I’m no expert but what I see is you are overwhelming yourself: you start on self esteem, then wander into study/attention issues, the close with relationship problems.

If you start by focusing on you, and forget the rest, then break things into chunks. Your meds may/may not be wrong. You might need to try another kind such as Adderall or similar. This might alleviate the focus in class issues. Which takes me to the next part…

You know you’re not stupid, you’re interested, and cannot study or recall well. The meds might help but the point is that you need to get focused, pass the exams, and get a way to make a decent living. Once done, that’s a major step toward 1) focus/attention/retention, and 2) self esteem – you’ve accomplished a lot. You might consider a private chat with the course counselors or teacher in nursing to advise of your ADD, and ask if there’s any help available for course takers. Temper that with whether you think the instructor(s) will be receptive or not. If not, don’t do it. lastly, try repetition or writing things out until it sinks in. Painful, time-consuming, but it works for me.

Lastly on relationships. (I struggle there too), but an old sales trick that makes me more comfortable is to ask “what is the worst than can happen”? i.e. if you stick your hand up in class, and ask a question (while mortified it’s a dumb one), what’s the worst that can happen? Maybe some dufus might laugh at you, but you will get an answer from the teacher, and learn that it’s OK to ask. Remember, you paid for this, demand your money’s worth!

Good luck, Jim

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[JimC.]

I stopped the meds on the advice of the clinic, and also out of curiosity. It was clear almost immediately that the meds were needed, regardless of what they claimed. I couldn’t beleive how fast I fell back into my old patterns of procrastination. Next day, back on Adderall, things were “back to normal”.

The feedback consisted only of listening to tones, and watching the odd packman-like video with tones associated with action. I felt no change nor difference, but stopped as I felt the impact was minimal for the $ I would likely have to spend. Call it my experiment. I am having far better results with the links I found on this site, such as the DIY cognitive therapy sessions on line and journal keeping FWIW.

Just my .02, Jim

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[JimC.]

I’ve known I’ve been ADD for about 8 years now, but going through a separation has me on a mission from God to really try to understand absolutely everything about ADD. I know it was my negativity that caused the breakup, so how do I fix that? (asking myself). I’ve been immersed in all things ADD and then some. What was the question? Oh yes…

So yes, Elizabeth, I am constantly thinking about it and if others will listen, I tell them I’m ADD, and how that affects me in specific situations. Surprisingly they seem interested. i.e. I was asked to join a board on a volunteer basis, and after I explained I would be inattentive, impatient, ineffectual and a whole bunch of other “ins” they got the picture. Then I offered to help in a way I know I could contribute, and thanked them for flattering me by asking to join the board in the first place.

I’ve been yakking up a storm and so far, I feel better about things and myself. go figure.

Jim (back to taking the Mood Gym tests and workbook).

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[JimC.]

DulcisMinutiae: thanks, pardon my impatience. jc

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[JimC.]

DulcisMinutiae: how does one get your recommended video to run in English?http://www.ted.com/talks/srikumar_rao_plug_into_your_hard_wired_happiness.html

jc

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[JimC.]

OK found the book. It’s lengthy for a forum but here goes…. “ADD & Romance – finding fulfillment in Love, Sex, & Relationships. Jonathon Halverstadt, MS.

Covered are 1)making poor partnering choices; 2) unrealistic ADD expectations 3) challenge of good communications 4) sexual intimacy and ADD, the erratic/erotic attention span; 5) positive attributes of Add in a romantic relationship 6) making your love last 7) help for the hurting Sweetheart approach 9) Fifty ways to keep your lover.

Some you’ve heard before, some not. Parts seem good, if only I could a) remember them and the b) use them. Why don’t they write things on a 9″ nail that could be pounded into my forehead?

Here’re some cut/paste reviews from Amazon.ca – $13.99 there….

A.D.D. & Romance is a “Must Read” if you have Attention Deficit Disorder and you are involved in a romantic relationship!

This easy to read book is a “gold mine” of practical information that can be used by folks who have ADD as well as their partners to enrich their romantic relationship(s).

Jonathan Scott Halverstadt, M.S. is up to date on the latest research and theory related to attention deficit disorder. He speaks “from the heart” and I guarantee you this book is just “packed with information” that will help you to understand your own romantic behavior and will give you lots of tips and strategies to make the most of your romantic relationship(s).

I’ve read at least ten books on ADD and many of them were very helpful to me. However, A.D.D. & Romance by Jonathan Scott Halverstadt, M.S. is by far the best book I’ve read on the subject of ADD and romance.

5.0 out of 5 stars helpful in understanding how &why i function as i do, Nov 10 2002

By newly diagnosed college student (north carolina, usa) – See all my reviews

i found this book to be extremely helpful. everything i’ve read deals with what makes someone add and ways to deal with add (ie. meds and orginational skills). being that i was only 17 when i first read it, i did not apply it to any kind of romantic relationship but to realtionships with my parents and my friends. more importantly it made me very aware of some the bad, hurtful habits i have (like interupting) that i didn’t even relieze 1)that i was doing it and 2) that they might really be hurting people and my relationships with them. Help other customers find the most helpful reviews

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2.0 out of 5 stars Poorly written, Sep 5 2002

By A Customer

While this book may contain some good information and practical advice, I could not get past the sloppily written introduction or langorous details of chapter 1. A good editor would have been a godsend for this topic.

What was the question again? :o/

Jim

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[JimC.]

I’m 63 with Adderall 20mg 1x a day. Very active, 0 BP issues 125/80. I run hard and bike hard. Adderall helps my focus and procrastination; neuro I tried a bit and the only effect was to lighten my wallet, a LOT. Try everything else 1st, and get an evaluation too. Good luck, jc

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[JimC.]

I posted somewhere on here, but FWIW, I did about 10 sessions at great cost with Dr. Swingle & Associates in Vancouver. After 10 visits or so, I was advised I should be able to stop meds. The first day I fell immediately into the old pattern of procrastination; my meds help me bypass that. So my experience is to try other routes like coaching, cog. therapy, and using the lists of tools that are at hand.

Just my .02, Jim

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[JimC.]

I recently bought a self help book on love, relationships and sex for ADD’rs. I read it voraciously. I cannot recall a single recommendation, let me get back to you.

jc

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[JimC.]

this may/may not relate…here goes. I quit smoking in 1987 and shot up 20-25 lbs. Ever since then, I’ve been trying to lose it but the ice cream gets in the way. and the snacks, treats, cookies, buns, you name it.

1) get the temptations out of your home; if it’s not there it’s not calling to you. I’ve never had any luck with supportive spouses with this, but now that I’m single again, it’s easy to just not have all that cr@p around.

2) find a sport or exercise you like, and do it regularly. Take care of you; make that time work, and dump anything/anyone that gets in the way. I love to cycle, so do it every chance I get.

Bottom line: I keep my weight in line, and slowly I am dropping a pound here, a pound there.

Be good to you – with exercise and fun, not food. Sell all your diet books and buy yourself a present, then make a plan.

Good luck, Jim

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[JimC.]

That’s me too. One point the original show picked up on: find the right career. Numbers and spreadsheets are pure poison for me, maybe you two also. Try working at getting another job that is not involved with numbers, crunching, deadlines, and such. Jim – yes I realize far easier said than done.

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